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Diabetes

The missing link with obesity?

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The molecular mechanisms underlying the link between obesity and diabetes have been elusive. A new protein, christened 'resistin', can now be added to the panoply of factors that may be involved.

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Figure 1: Obesity causes certain tissues in the body (such as muscle and liver) to be less sensitive to insulin.

References

  1. Steppan, C. M. et al. Nature 409, 307–312 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Kahn, B. B. & Flier, J. S. J. Clin. Invest. 106 , 473–481 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Boden, G. Proc. Assoc. Am. Physicians 111, 241– 248 (1999).

    Article  CAS  PubMed  Google Scholar 

  4. Hotamisligil, G. S., Peraldi, P. & Spiegelman, B. M. Curr. Opin. Endocrinol. Diab. 3, 16–23 (1996).

    Article  CAS  Google Scholar 

  5. Friedman, J. M. & Halaas, J. L. Nature 395, 763–770 (1998).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Ahima, R. S. & Flier, J. S. Annu. Rev. Physiol. 62, 413–437 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S. & Goldstein, J. L. Nature 401, 73–76 (1999).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Considine, R. V. et al. New Engl. J. Med. 334, 292– 295 (1995).

    Article  Google Scholar 

  9. Olefsky, J. M. J. Clin. Invest. 106, 467–472 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Lehmann, J. M. et al. J. Biol. Chem. 270, 12953– 12956 (1995).

    Article  CAS  PubMed  Google Scholar 

  11. Tontonoz, P. et al. Genes Dev. 8, 1224– 1234 (1994).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Beth Israel Deaconess Medical Center, Research North 325, 99 Brookline Avenue, Boston, 02215, Massachusetts, USA

    Jeffrey S. Flier

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  1. Jeffrey S. Flier
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Correspondence to Jeffrey S. Flier.

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Flier, J. The missing link with obesity?. Nature 409, 292–293 (2001). https://doi.org/10.1038/35053251

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