Skip to main content
SpringerLink
Log in

Together until separin do us part

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Loss of sister-chromatid cohesion triggers chromosome segregation. Several recent reports show that the protease Esp1 cleaves the cohesin subunit Scc1/Mcd1 to induce sister-chromatid segregation in yeast and vertebrates. This finding indicates that cohesin cleavage may control sister-chromatid separation in all eukaryotes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Control of sister-chromatid cohesion in yeast and vertebrates.

References

  1. Koshland, D., & Guacci, V. Curr. Opin. Cell Biol. 12, 297–301 ( 2000).

    Article  CAS  Google Scholar 

  2. Nasmyth, K., Peters, J. M. & Uhlmann, F. Science 288, 1379– 1386 (2000).

    Article  CAS  Google Scholar 

  3. Uhlmann, F., Lottspeich, F. & Nasmyth, K. Nature 400, 37– 42 (1999).

    Article  CAS  Google Scholar 

  4. Uhlmann, F. et al. Cell 103, 375–386 (2000).

    Article  CAS  Google Scholar 

  5. Waizenegger, I. C., Hauf, S., Meinke, A. & Peters, J. M. Cell 103, 399–410 ( 2000).

    Article  CAS  Google Scholar 

  6. Tomonaga, T., et al. Genes Dev. 14, 2757– 2770.

  7. Buonomo, S. B. C. et al. Cell 103, 387–398 (2000).

    Article  CAS  Google Scholar 

  8. Losada, A., Yokochi, T., Kobayashi, R. & Hirano, T. J. Cell Biol 150, 405–416 (2000).

    Article  CAS  Google Scholar 

  9. Sumara, I. et al. J. Cell Biol. 151, 749– 762 (2000).

    Article  CAS  Google Scholar 

  10. Darwiche, N., Freeman, L. A. & Strunnikov, A. Gene 233, 39– 47 (1999).

    Article  CAS  Google Scholar 

  11. Pezzi, N. et al. FASEB J. 14, 581–592.

  12. Stoop-Myer, C. & Amon, A. Nature Cell Biol. 1, E125–E127 ( 1999).

    Article  CAS  Google Scholar 

  13. Wanatabe, Y. & Nurse, P. Nature 400 , 461–464 (1999).

    Article  Google Scholar 

  14. Peters, J-M. Curr. Biol. 10, 759–768 (1998).

    Article  CAS  Google Scholar 

  15. Losada, A., Hirano, M. & Hirano, T. Genes Dev. 12, 1986– 1997 (1998).

    Article  CAS  Google Scholar 

  16. Kerrebrock, A. W., Moore, D. P., Wu, J. S. & Orr-Weaver, T. L. Cell 83, 247–256 ( 1995).

    Article  CAS  Google Scholar 

  17. Tang, T. T. L., Bickel, S. E., Young, L. M. & Orr-Weaver, T. L. Genes Dev. 12, 3843–3856 (1998).

    Article  CAS  Google Scholar 

  18. Miyazaki, W. Y. & Orr-Weaver, T. L. Annu. Rev. Genet. 28, 167–187 ( 1994).

    Article  CAS  Google Scholar 

  19. Peter, M. et al. Nature Cell Biol. 3, 83– 87 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA

    Angelika Amon

Authors
  1. Angelika Amon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Amon, A. Together until separin do us part. Nat Cell Biol 3, E12–E14 (2001). https://doi.org/10.1038/35050642

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35050642

  • Springer Nature Limited

This article is cited by

Search

Navigation