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The ins and outs of p53

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Moving proteins between cellular locations is proving to be a tightly regulated process, and provides an important mechanism for controlling protein function. The tumour-suppressor protein p53 has been shown to use microtubules to aid nuclear localization, a finding that raises interesting questions about the action of microtubule-disrupting chemotherapeutic drugs.

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Figure 1: Model for regulation of the subcellular localization of p53.

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Authors and Affiliations

  1. the National Cancer Institute , Frederick, 21702, Maryland, USA

    Karen H. Vousden

  2. the Van Andel Research Institute, 333 Bostwick Northeast, Grand Rapids , 49503, Michigan, USA

    George F. Vande Woude

Authors
  1. Karen H. Vousden
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  2. George F. Vande Woude
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Vousden, K., Woude, G. The ins and outs of p53. Nat Cell Biol 2, E178–E180 (2000). https://doi.org/10.1038/35036427

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