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Anaphase spindle position is monitored by the BUB2 checkpoint

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Figure 1: Improper orientation of anaphase spindles causes a BUB2-dependent delay in mitotic exit.
Figure 2: dyn1 bub2 mutants do not arrest with misorientated spindles produce anucleate cells.

References

  1. Li, R. & Murray, A. W. Cell 66, 519–531 (1991).

    Article  CAS  Google Scholar 

  2. Hoyt, M. A., Totis, L. & Roberts, B. T. Cell 66, 507– 517 (1991).

    Article  CAS  Google Scholar 

  3. Fraschini, R., Formenti, E, Lucchini, G. & Piatti, S. J. Cell Biol. 145, 979–991 (1999).

    Article  CAS  Google Scholar 

  4. Alexandru, G., Zachariae, W., Schleiffer, A. & Nasmyth, K. EMBO J. 18, 2707–2721 ( 1999).

    Article  CAS  Google Scholar 

  5. Li, R. Proc. Natl Acad. Sci. USA 96, 4989–4994 (1999).

    Article  CAS  Google Scholar 

  6. Fesquet, D. et al. EMBO J. 18, 2424–2434 (1999).

    Article  CAS  Google Scholar 

  7. Lew, D. J. Curr. Opin. Genet. Dev. 10, 47–53 (2000).

    Article  CAS  Google Scholar 

  8. Burke, D. J. Curr. Opin. Genet. Dev. 10, 26–31 (2000).

    Article  CAS  Google Scholar 

  9. Yeh, E., Skibbens, R. V., Cheng, J. W., Salmon, E. D. & Bloom, K. J. Cell Biol. 130, 687–700 (1995).

    Article  CAS  Google Scholar 

  10. McMillan, J. N. & Tatchell, K. J. Cell Biol. 125, 143–158 ( 1994).

    Article  CAS  Google Scholar 

  11. Kahana, J. A. et al. Mol. Biol. Cell 9, 1741– 1756 (1998).

    Article  CAS  Google Scholar 

  12. Muhua, L., Karpova, T. S. & Cooper, J. A. Cell 78, 669– 679 (1994).

    Article  CAS  Google Scholar 

  13. Eshel, D. et al. Proc. Natl Acad. Sci. USA 90, 11172– 11176 (1993).

    Article  CAS  Google Scholar 

  14. Muhua, L., Adames, N. R., Murphy, M. D., Shields, C. R. & Cooper, J. A. Nature 393, 487–491 (1998).

    Article  CAS  Google Scholar 

  15. Tirnauer, J. S., O’Toole, E., Berrueta, L., Bierer, B. G. & Pellman, D. J. Cell Biol. 145, 993– 1007 (1999).

    Article  CAS  Google Scholar 

  16. Schwartz, K., Richards, K. & Botsten, D. Mol. Biol. Cell 8, 2677– 2691 (1997).

    Article  CAS  Google Scholar 

  17. Lee, L. et al. Science 287, 2260–2262 (2000).

    Article  CAS  Google Scholar 

  18. Korinek, W. S., Copeland, M. J., Chaudhuri, A. & Chart, J. Science 287, 2257–2259 ( 2000).

    Article  CAS  Google Scholar 

  19. Balasubramanian, M. K., McCollum, D. & Surana, U. J. Cell Sci. 113, 1503– 1513 (2000).

    CAS  PubMed  Google Scholar 

  20. Rhyu, M. S. & Knoblich, J. A. Cell 82, 523–526 (1995).

    Article  CAS  Google Scholar 

  21. Bloecher, A. & Tatchell, K. Genes Dev. 13, 517–522 (1999).

    Article  CAS  Google Scholar 

  22. Bloecher, A. & Tatchell, K. J. Cell Biol. 149, 125–140 (2000).

    Article  CAS  Google Scholar 

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Acknowledgements

We thank L. Robinson, N. Mathias and E. Aamodt for comments on the manuscript, and D. Burke, A. Straight and A. Murray for strains, plasmids and helpful discussion. We also thank D. Burke for sharing data before publication. This work was supported by National Institutes of Health grant GM-477899.

Correspondence and requests for materials should be addressed to K.T. Supplementary Information is available on Nature Cell Biology’s World Wide Web site (http://www.nature.com/ncb).

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  1. Andrew Bloecher

    Present address: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington, 98109, USA

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway , Shreveport, 71130, Louisiana, USA

    Andrew Bloecher, Guglielmo M. Venturi & Kelly Tatchell

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  1. Andrew Bloecher
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  2. Guglielmo M. Venturi
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  3. Kelly Tatchell
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Bloecher, A., Venturi, G. & Tatchell, K. Anaphase spindle position is monitored by the BUB2 checkpoint. Nat Cell Biol 2, 556–558 (2000). https://doi.org/10.1038/35019601

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