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Calcium-dependent modulation by melatonin of the circadian rhythm in malarial parasites.

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Figure 1: Melatonin increases parasitemia and promotes maturation of P. falciparum and P. chabaudi.
Figure 2: Effect of melatonin on cytosolic [Ca2+]i in intact P. chabaudi cells.

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Acknowledgements

This work was supported by grants from the Fundação de Amparo à Pesquisa de São Paulo (FAPESP) and from the Conselho Nacional de Desenvolvimento Científico e Tecnólogico (CNPq) to C.R.S.G. and R.P.M., and by grants from the University of Padova, from UNESCO and from the Harvard Armenise Foundation to T.P. We thank S. D. Santi from SUCEN for help with P. falciparum culture and A. Thomas for helpful discussions .

Correspondence and requests for materials should be addressed to C.R.S.G.

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Authors and Affiliations

  1. Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, 05508-90, Brasil

    Carlos T. Hotta, Marcos L. Gazarini, Flávio H. Beraldo, Fernando P. Varotti, Cristiane Lopes, Regina P. Markus & Célia R. S. Garcia

  2. Dipartimento di Scienze Biomediche Sperimentali, Centro CNR ‘Biomembrane’, Universita’ di Padova, Padova, 35121, Italy

    Tullio Pozzan

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  1. Carlos T. Hotta
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Correspondence to Célia R. S. Garcia.

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Hotta, C., Gazarini, M., Beraldo, F. et al. Calcium-dependent modulation by melatonin of the circadian rhythm in malarial parasites.. Nat Cell Biol 2, 466–468 (2000). https://doi.org/10.1038/35017112

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