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Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

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Figure 1: Absence of Aβ production in PS1/PS2 double-knockout cells.
Figure 2: Absence of NICD production in PS1/PS2 double-knockout cells.

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Acknowledgements

This work was supported by grants from the NIH and a Zenith Award from the Alzheimer’s Association (to B.A.Y), by fellowships from the Medical Foundation (to Z.Z.) and from the Edward R. and Anne G. Lefler Foundation (to P.N), and by an NIH MRRC Core grant.

Correspondence and requests for materials should be addressed to B.A.Y.

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Author notes

  1. Zhuohua Zhang, Philip Nadeau, Weihong Song, Dorit Donoviel and Alan Bernstein: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Harvard Medical School and Division of Neuroscience, Children’s Hospital, Boston, 02115, MA, USA

    Zhuohua Zhang, Philip Nadeau, Weihong Song, Menglan Yuan & Bruce A. Yankner

  2. Mount Sinai Hospital and Department of Medical Genetics and Microbiology, Samuel Lunenfeld Research Institute, University of Toronto, Toronto, M5S-1A8, Canada

    Dorit Donoviel & Alan Bernstein

Authors
  1. Zhuohua Zhang
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  2. Philip Nadeau
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  3. Weihong Song
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  4. Dorit Donoviel
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  5. Menglan Yuan
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  6. Alan Bernstein
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  7. Bruce A. Yankner
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Corresponding author

Correspondence to Bruce A. Yankner.

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Zhang, Z., Nadeau, P., Song, W. et al. Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1. Nat Cell Biol 2, 463–465 (2000). https://doi.org/10.1038/35017108

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  • DOI: https://doi.org/10.1038/35017108

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