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Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

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Figure 1: Presenilin-deficient embryonic stem cells lack γ-secretase activity.

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Acknowledgements

This work was supported by the Bayer Alzheimer research network (BARN), the Human Frontier of Science Program (HFSP) and the Fund for Scientific Research, Flanders (FWO).

Correspondence and requests for materials should be addressed to B.D.S.

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Authors and Affiliations

  1. Neuronal Cell Biology Laboratory, CME, K.U.Leuven and Flanders Interuniversitary Institute for Biotechnology (VIB4), Herestraat 49, Leuven, 3000, Belgium

    An Herreman, Lutgarde Serneels, Wim Annaert & Bart De Strooper

  2. Thromb–X, NV, Herestraat 49, Leuven, 3000, Belgium

    Desiré Collen & Luc Schoonjans

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  1. An Herreman
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  2. Lutgarde Serneels
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  3. Wim Annaert
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  4. Desiré Collen
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  5. Luc Schoonjans
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  6. Bart De Strooper
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Correspondence to Bart De Strooper.

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Herreman, A., Serneels, L., Annaert, W. et al. Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells. Nat Cell Biol 2, 461–462 (2000). https://doi.org/10.1038/35017105

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