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References
Haass, C. & Selkoe, D. J. Cell 75, 1039–1042 (1993).
Hussain, I. et al. Mol. Cell. Neurosci. 14, 419– 427 (1999).
Sinha, S. et al. Nature 402, 537–540 (1999).
Vassar, R. et al. Science 286, 735–741 (1999).
Yan, R. et al. Nature 402, 533–537 (1999).
Li, Y.-M et al. Nature 405, 689–694 (2000).
Esler, W. P. et al. Nature Cell Biol. (in the press).
Scheuner, D. et al. Nature Med. 2, 864– 870 (1996).
Haass, C. & De Strooper, B. Science 286, 916–919 (1999).
De Strooper, B. et al. Nature 391, 387–390 (1998).
Zhang, Z. et al. Nature Cell Biol. (in the press).
Herreman, A. et al. Nature Cell Biol. (in the press).
Wolfe, M. S. et al. Nature 398, 513–517 (1999).
Thinakaran, G. et al. Neuron 17, 181–190 (1996).
Brown, M. S., Ye, J., Rawson, R. B. & Goldstein, J. L. Cell 100, 391–398 (2000).
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De Strooper, B. Closing in on γ-secretase. Nature 405, 627–628 (2000). https://doi.org/10.1038/35015193
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DOI: https://doi.org/10.1038/35015193
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