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Different site, different splice

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Abstract

The MKK3/6–p38 pathway has been found to induce the relocalization of premessenger-RNA splicing factors from the nucleus to the cytoplasm. This represents the first physiological mechanism that alters the nuclear ratios of splicing factors and modulates alternative splice-site choice in vivo.

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Figure 1: The ratio of the splicing factors SF2/ASF relative to hnRNP A1 controls alternative 5′ splice-site choice.

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Authors and Affiliations

  1. the National Cancer Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Tom Misteli

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  1. Tom Misteli
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Misteli, T. Different site, different splice. Nat Cell Biol 2, E98–E100 (2000). https://doi.org/10.1038/35014091

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