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TRAIL receptor-2 signals apoptosis through FADD and caspase-8

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Figure 1: Time course of recruitment of FADD and caspase-8 to TRAIL receptors.
Figure 2: Impaired TRAIL-R2 signalling pathway in mutant Jurkat T-cell lines that are defective in caspase-8 or FADD expression.

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Acknowledgements

We thank S. Masina and M. Thome for critical reading of the manuscript and for discussions, and S. Aslan for editorial assistance. This work was supported by grants from the Swiss National Science Foundation (to J.T.).

Correspondence and requests for materials should be addressed to J.T.

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Authors and Affiliations

  1. Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066, Epalinges, Switzerland

    Jean-Luc Bodmer, Nils Holler, Séverine Reynard, Patrizia Vinciguerra, Pascal Schneider & Jürg Tschopp

  2. Department of Cell Biology, Harvard Medical School , Boston, Massachusetts, 02115, USA

    Peter Juo & Joe Blenis

Authors
  1. Jean-Luc Bodmer
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  2. Nils Holler
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  3. Séverine Reynard
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  4. Patrizia Vinciguerra
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  6. Peter Juo
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  8. Jürg Tschopp
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Correspondence to Jürg Tschopp.

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Bodmer, JL., Holler, N., Reynard, S. et al. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol 2, 241–243 (2000). https://doi.org/10.1038/35008667

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