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Naked antigen-presenting molecules on dendritic cells

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Abstract

Antigen-presenting cells work to present peptides derived from exogenous and endogenous antigens to circulating T cells, sparking off an immune response. Dendritic cells are unique amongst antigen-presenting cells, not least for their newly described ability to circumvent the need to internalize exogenous antigens before presenting them.

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Figure 1: Three pathways for loading major histocompatibility complex (MHC) class II molecules with peptides in dendritic cells.
Figure 2: Possible roles of empty surface major histocompatibility complex (MHC) class II molecules.

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Authors and Affiliations

  1. the Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, 75204, Texas, USA

    Jean Davoust & Jacques Banchereau

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  1. Jean Davoust
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  2. Jacques Banchereau
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Correspondence to Jacques Banchereau.

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Davoust, J., Banchereau, J. Naked antigen-presenting molecules on dendritic cells. Nat Cell Biol 2, E46–E48 (2000). https://doi.org/10.1038/35004075

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