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Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

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Abstract

Using an approach for isolating and characterizing peptide fractions that are intracellularly associated with major histocompatibility complex class I molecules, the major peptide recognized by cytotoxic T cells specific for the vesicular stomatitis virus has been isolated from the H–2Kb molecule of infected cells. This endogenously processed octapeptide is allele-specific as it does not bind to H–2Db molecules, and contains the core sequence of the epitope of the nucleocapsid protein of the vesicular stomatitis virus identified by testing with exogenous synthetic peptides.

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Authors and Affiliations

  1. Department of Cell Biology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA

    Grada M. Van Bleek & Stanley G. Nathenson

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  1. Grada M. Van Bleek
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  2. Stanley G. Nathenson
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Bleek, G., Nathenson, S. Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule. Nature 348, 213–216 (1990). https://doi.org/10.1038/348213a0

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  • DOI: https://doi.org/10.1038/348213a0

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