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Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

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Abstract

By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.

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Author information

Author notes

  1. Joachim Ostermann

    Present address: Department of Biology, Princeton University, Princeton, New Jersey, 08544-1014, USA

Authors and Affiliations

  1. Department of Physiological Chemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA

    Pil-Jung Kang, Jeffery Shilling & Elizabeth A. Craig

  2. Institut für Physiologische Chemie, Universität; München, Goethestrasse 33, D-8000, München, 2, FRG

    Joachim Ostermann, Walter Neupert & Nikolaus Pfanner

Authors
  1. Pil-Jung Kang
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  2. Joachim Ostermann
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  3. Jeffery Shilling
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  4. Walter Neupert
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  5. Elizabeth A. Craig
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  6. Nikolaus Pfanner
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Kang, PJ., Ostermann, J., Shilling, J. et al. Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature 348, 137–143 (1990). https://doi.org/10.1038/348137a0

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  • DOI: https://doi.org/10.1038/348137a0

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