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Regulation of the mevalonate pathway

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Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

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  1. Departments of Molecular Genetics and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75235, USA

    Joseph L. Goldstein & Michael S. Brown

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  2. Michael S. Brown
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Goldstein, J., Brown, M. Regulation of the mevalonate pathway. Nature 343, 425–430 (1990). https://doi.org/10.1038/343425a0

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