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Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

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Abstract

Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochon-dria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.

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Author notes

  1. Arthur L. Horwich: Yale University School of Medicine, Department of Human Genetics, 333 Cedar Street, New Haven, Connecticut 06510, USA

Authors and Affiliations

  1. Institut für Physiologische Chemie der Universität München, Goethestrasse 33, 8000, München, 2, FRG

    Joachim Ostermann, Arthur L. Horwich, Walter Neupert & F.-Ulrich Hartl

Authors
  1. Joachim Ostermann
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  2. Arthur L. Horwich
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  3. Walter Neupert
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  4. F.-Ulrich Hartl
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Ostermann, J., Horwich, A., Neupert, W. et al. Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature 341, 125–130 (1989). https://doi.org/10.1038/341125a0

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