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Association of class I major histocompatibility heavy and light chains induced by viral peptides

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Abstract

We describe a cell in which association of a major histocompatibility complex class I heavy chain with β2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of anti-genie peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with β2-microglobulin and transport of the antigen-MHC complex to the cell surface.

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Authors and Affiliations

  1. Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, 0X3 9DU, UK

    Alain Townsend, Judy Bastin & Linda Foster

  2. Department of Tumour Biology, Karolinska Institute, Box 60400, S-104 01, Stockholm, Sweden

    Claes Öhlén, Hans-Gustaf Ljunggren & Klas Kärre

Authors
  1. Alain Townsend
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  2. Claes Öhlén
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  3. Judy Bastin
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  4. Hans-Gustaf Ljunggren
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  5. Linda Foster
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  6. Klas Kärre
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Townsend, A., Öhlén, C., Bastin, J. et al. Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340, 443–448 (1989). https://doi.org/10.1038/340443a0

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