Skip to main content

Advertisement

SpringerLink
Log in

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

TOLERANCE to self-antigens has been shown to develop during ontogeny as a result of the elonal deletion of self-reactive T cells1–4. Tolerance, or better 'nonresponsiveness', to specific antigens can also be induced in adult animals5–9 but the mechanism(s) involved are not well understood10. Most murine T-helper cells that express the Vβ6 T-cell receptor gene segment are specific for Mls-1a antigens3. We have therefore been able to use an anti-Vβ6 monoclonal antibody to follow the fate of Mls-1a specific T cells in adult Mls-1b mice made specifically unresponsive to Mls-1a. We show that the induced unresponsiveness is not due to elonal deletion, but rather to elonal anergy. The anergic Vβ6 T-helper cells express IL-2 receptors and undergo limited blastogenesis in vitro upon stimulation, but do not produce IL-2, in marked contrast to Vβ6 cells from naive mice. Our data appear to represent an in vivo correlate for the induction of anergy that has been observed in T-cell lines in vitrol l–15.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kappler, J. W., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).

    Article  CAS  PubMed  Google Scholar 

  2. Kappler, J. W., Staerz, U., White, J. & Marrack, P. C. Nature 332, 35–40 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. MacDonald, H. R. et al. Nature 40–45 (1988).

  4. Kisielow, P., Blüthmann, H., Staerz, U. D., Steinmetz, M. & von Boehmer, H. Nature 333, 742–746 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Jacobson, J., Lilliehöök, B. & Blomgren, H. Scand. J. Immun. 4, 181–191 (1975).

    Article  Google Scholar 

  6. Lilliehöök, B., Jacobson, H. & Blomgren, H. Scand. J. Immun. 4, 209–216 (1975).

    Article  Google Scholar 

  7. Miller, S. D., Sy, M.-S. & Claman, H. N. Eur. J. Immunol. 7, 165–170 (1977).

    Article  CAS  PubMed  Google Scholar 

  8. Brondz, B. D., Karanlov, A. V., Abronina, I. F. & Blandova, L. K. Scand. J. Immun. 13, 517–534 (1981).

    Article  CAS  Google Scholar 

  9. Jenkins, M. K. & Schwartz, R. H. J. exp. Med. 165, 302–319 (1987).

    Article  CAS  PubMed  Google Scholar 

  10. von Boehmer, H., Teh, H. S. & Kisielow, P. Immun. Today 10, 577–61 (1989).

    Article  Google Scholar 

  11. Markmann, J. et al. Nature 336, 476–479 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Lamb, J. R. et al. J. exp. Med. 157, 1434–1447 (1983).

    Article  CAS  PubMed  Google Scholar 

  13. Lamb, J. R. & Feldmann, M. Nature 308, 72–74 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Quill, H. & Schwartz, R. H. J. Immun. 138, 3704–3712 (1987).

    CAS  PubMed  Google Scholar 

  15. Jenkins, M. K., Pardoll, D. M., Mizuguchi, J., Chused, T. M. & Schwartz, R. H. Proc. natn. Acad. Sci. U.S.A. 84, 5409–5413 (1987).

    Article  ADS  CAS  Google Scholar 

  16. Festenstein, H. Transplantn Rev. 15, 62–88 (1973).

    CAS  Google Scholar 

  17. Abe, R. & Hodes, R. J. Immun. Today 9, 230–235 (1988).

    Article  CAS  PubMed  Google Scholar 

  18. Halle-Pannenko, O., Pritchard, L. L. & Bruley-Rosset, M. Eur. J. Immun. 17, 1751–1755 (1987).

    Article  CAS  Google Scholar 

  19. von Boehmer, H. & Schubiger, K. Eur. J. Immun. 14, 1048–1052 (1984).

    Article  CAS  Google Scholar 

  20. Ready, A. R., Jenkinson, E. J., Kingston, R. & Owen, J. J. I. Nature 310, 231–233 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Flajnik, M. F., DuPasquier, L. & Cohen, N. Eur. J. Immun. 15, 540–547 (1985).

    Article  CAS  Google Scholar 

  22. Ohki, H., Martin, C., Corbel, C., Coltey, M. & Le Douarin, N. M. Science 237, 1032–1035 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  23. Marrack, P. et al. Cell 53, 627–634 (1988).

    Article  CAS  PubMed  Google Scholar 

  24. Nossal, G. J. V. & Pike, B. L. Proc. natn. Acad. Sci. U.S.A. 77, 1602–1606 (1980).

    Article  ADS  CAS  Google Scholar 

  25. Goodnow, C. C. et al. Nature 334, 676–682 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Janeway, C. A., Jr., Fischer-Lindahl, K. & Hämmerling, U. Immun. Today 9, 125–126 (1988).

    Article  PubMed  Google Scholar 

  27. Payne, J. et al. Proc. natn. Acad. Sci. U.S.A. 85, 7695–7698 (1988).

    Article  ADS  CAS  Google Scholar 

  28. Dialynas, D. P. et al. J. Immun. 131, 2445–2451 (1983).

    CAS  PubMed  Google Scholar 

  29. Malek, T. R., Robb, R. J. & Shevach, E. M. Proc. natn. Acad. Sci. U.S.A. 80, 5694–5698 (1983).

    Article  ADS  CAS  Google Scholar 

  30. Ceredig, R., Lowenthal, J. W., Nabholz, M. & MacDonald, H. R. Nature 314, 98–100 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Bernard Frangoulis

    Present address: Institut de Recherches sur les Maladies du Sang, Hopital Saint-Louis, 2, Place Fournier, Paris, France

Authors and Affiliations

  1. Max-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400, Tübingen, FRG

    Hans-Georg Rammensee, Ruth Kroschewski & Bernard Frangoulis

Authors
  1. Hans-Georg Rammensee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ruth Kroschewski
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bernard Frangoulis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rammensee, HG., Kroschewski, R. & Frangoulis, B. Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells. Nature 339, 541–544 (1989). https://doi.org/10.1038/339541a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/339541a0

  • Springer Nature Limited

This article is cited by

Search

Navigation