Abstract
A newly-constructed antibody-like molecule containing the gp!20-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.
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Capon, D., Chamow, S., Mordenti, J. et al. Designing CD4 immunoadhesins for AIDS therapy. Nature 337, 525–531 (1989). https://doi.org/10.1038/337525a0
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DOI: https://doi.org/10.1038/337525a0
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