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A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

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Abstract

The complementary DNA coding for a lymphocyte-specific transcription factor binding to the DNA 'octamer' sequence TNATTTGCAT has been cloned. The nucleotide sequence shows homology to the homoeobox domain. Expression of this cDNA in HeLa cells is sufficient for a strong transcriptional activation of E-cell-specific promoters.

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Author notes

  1. Siegfried Ruppert: Deutsches Krebsforschungszentrum, im Neuenheimer Feld 280, D-6900 Heidelberg, FRG

Authors and Affiliations

  1. Institut für Molekularbiologie II der Universität Zürich, Hönggerberg, CH-8093, Zürich, Switzerland

    Michael M. Müller, Siegfried Ruppert, Walter Schaffner & Patrick Matthias

Authors
  1. Michael M. Müller
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  2. Siegfried Ruppert
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  3. Walter Schaffner
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  4. Patrick Matthias
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Müller, M., Ruppert, S., Schaffner, W. et al. A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells. Nature 336, 544–551 (1988). https://doi.org/10.1038/336544a0

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  • DOI: https://doi.org/10.1038/336544a0

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