Abstract
Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric αβ T-cell receptor (TCR)1,2. CD4 and CDS molecules expressed on the surface of T cells bind to nonpolymorphic portions of class II and class I MHC molecules and assist the TCR in binding and possibly in signalling3,4. The analysis of T-cell development in TCR transgenic mice has shown that the CD4/CD8 phenotype of T cells is determined by the interaction of the αβ TCR expressed on immature CD4+8+ thymocytes with polymorphic domains of thymic MHC molecules in the absence of nominal antigen5. Here we provide direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4−8+ T cells in the thymus requires the specific interaction of the αβ TCR with the restricting class I MHC molecule.
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References
Dembic, Z. et al. Nature 320, 232–238 (1986).
Saito, T. et al. Nature 325, 125–130 (1987).
Gabert, J. et al. Cell 50, 545–554 (1987).
Gay, D. et al. Nature 328, 626–629 (1987).
Teh, H. S. et al. Nature 335, 229–233 (1988).
Kisielow, P. et al. Nature 333, 742–746 (1988).
Staerz, U., Rammensee, H., Benedetto, J. & Bevan, M. J. Immun. 134, 3994–4000 (1985).
Bevan, M. J. Proc. natn. Acad. Sci. U.S.A. 74, 2094–2098 (1977).
Lemmonier, F., Burakoff, S. J., Germain, R. N. & Benaceraff, B. Proc. natn. Acad. Sci. U.S.A. 74, 1229–1233 (1977).
Sredni, B. & Schwartz, R. H. Immun. Rev. 54, 187–223 (1981).
von Boehmer, H. et al. Eur. J. Immun. 9, 592–597 (1979).
Bevan, M. J. Nature 269, 417–419 (1977).
Zinkernagel, R. M. et al. J. exp. Med. 147, 882–896 (1987).
von Boehmer, H., Haas, W. & Jerne, N. K. Proc. natn. Acad. Sci. U.S.A. 75, 2434–2442 (1978).
Kappler, J. & Marrack, P. J. J. exp. Med. 148, 1510–1522 (1978).
Klein, J. in Immunology: the Science of Self-Non-Self Discrimination 267 (Wiley, New York, 1982).
Matzinger, P. Nature 292, 497–499 (1981).
Egorov, I. K., Mnatsakanyan & Pospelov, L. E. Immunogenetics 5, 65–74 (1977).
Meo, T., Vives, J., Miggiano, V. & Shreffler, D. Trans. Proc. 5, 377–381 (1973).
Hünig, T. & Bevan, M. J. J. exp. Med. 155, 111–125 (1982).
Marrack, P. & Kappler, J. Nature 332, 840–843 (1988).
Teh, H. S., Bennink, J. & von Boehmer, H. Eur. J. Immun. 12, 887–892 (1982).
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Kisielow, P., Teh, H., Blüthmann, H. et al. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335, 730–733 (1988). https://doi.org/10.1038/335730a0
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DOI: https://doi.org/10.1038/335730a0
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