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Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

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Abstract

Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody. The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface IgM while continuing to express high levels of surface IgD. These findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance.

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Author notes

  1. Thomas B. Lavoie and Sandra J. Smith-Gill: Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

  2. Kathy Raphael: Division of Animal Production, CSIRO, Prospect, New South Wales, Australia

Authors and Affiliations

  1. Clinical Immunology Research Centre, University of Sydney, New South Wales, 2006, Australia

    Christopher C. Goodnow, Jeffrey Crosbie, Stephen Adelstein, Thomas B. Lavoie, Sandra J. Smith-Gill, Robert A. Brink, Helen Pritchard-Briscoe, John S. Wotherspoon, Robert H. Loblay, Kathy Raphael, Ronald J. Trent & Antony Basten

Authors
  1. Christopher C. Goodnow
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  2. Jeffrey Crosbie
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  3. Stephen Adelstein
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  4. Thomas B. Lavoie
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  5. Sandra J. Smith-Gill
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  6. Robert A. Brink
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  7. Helen Pritchard-Briscoe
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  8. John S. Wotherspoon
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  9. Robert H. Loblay
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  10. Kathy Raphael
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  11. Ronald J. Trent
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  12. Antony Basten
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Goodnow, C., Crosbie, J., Adelstein, S. et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334, 676–682 (1988). https://doi.org/10.1038/334676a0

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