Abstract
Processes as diverse as growth, vision and reproduction depend on the presence of vitamin A and its metabolites (retinoids), but the molecular mechanisms which govern these diverse actions remain unclear (for reviews see refs 1, 2). A crucial advance recently was the isolation of a specific nuclear receptor for retinoic acid3,4, one of the physiologically active vitamin A derivatives. This nuclear receptor is a member of the steroid/thyroid hormone receptor family. Our analysis of an uncharacterized member of this class of intracellular receptors, encoded by a complementary DNA clone from a human placental library, has led us to discover a second retinoic acid receptor. This new receptor is expressed at high levels in a number of epithelial-type tissues. The gene for the receptor was first identified in a hepatocellular carcinoma where it surrounds a site of integration of hepatitis B virus5. Activation by this virus may play a role in tumour development in liver cells, where it is normally not expressed.
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Benbrook, D., Lernhardt, E. & Pfahl, M. A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature 333, 669–672 (1988). https://doi.org/10.1038/333669a0
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DOI: https://doi.org/10.1038/333669a0
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