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cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

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Abstract

Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DMA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.

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Authors and Affiliations

  1. Department of Cardiovascular Research, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    John W. McLean, James E. Tomlinson, Dan L. Eaton & Richard M. Lawn

  2. Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Wun-Jing Kuang & Ellson Y. Chen

  3. Department of Medicine, Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, 60637, USA

    Gunther M. Fless & Angelo M. Scanu

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  1. John W. McLean
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  2. James E. Tomlinson
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  3. Wun-Jing Kuang
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  4. Dan L. Eaton
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  5. Ellson Y. Chen
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  6. Gunther M. Fless
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  7. Angelo M. Scanu
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  8. Richard M. Lawn
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McLean, J., Tomlinson, J., Kuang, WJ. et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 330, 132–137 (1987). https://doi.org/10.1038/330132a0

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