Abstract
Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).
Similar content being viewed by others
References
1. Gagel, R. F. et al. J. Paediat. 101, 941–946 (1982). 2. Simpson, N. E. & Kidd, K. K. Henry Ford Hosp. med. J. (in the press). 3. Liou, G. I. et al. Som. Cell molec. Genet, (in the press). 4. Davies, K. E. et al Nucleic Acids Res. 11, 2303–2312 (1983). 5. Gusella, J. F. et al. Nature 306, 234–238 (1983). 6. Reeders, S. T. et al. Nature 317, 542–544 (1985). 7. White, R. et al. Nature 318, 382–384 (1985). 8. Wainwright, B. J. et al. Nature 318, 384–385 (1985). 9. Kruger, S. D. et al. Hum. Hered. 36, 6–11 (1986). 10. Kidd, K. K. et al. Henry Ford Hosp. med. J. 32, 262–265 (1986). 11. Kidd, K. K., Castiglione, C. M., Pakstis, A. J. & Sparkes, R. S. Genet. Epidemiol. 3,195–200 (1986). 12. Kidd, K. K. et al. Hum. Hered. 36, 243–249 (1986). 13. Goodfellow, P. J. et al. Am. J. hum. Genet. 37, 890–897 (1985). 14. Pakstis, A. J. et al. Henry Ford Hosp. med. J. (in the press). 15. Carter, C. et al. Cytogenet. Cell Genet, (in the press). 16. Sarfarazi, M. et al. J. med. Genet. 24, (in the press). 17. Liou, G. I. et al. Nucleic Acids Res. 15, 3196 (1987). 18. Morton, N. Am. J. hum. Genet. 7, 277–318 (1955). 19. Lathrop, G. M., Lalouel, J. M., Julier, C. & Ott, J. Am. J. hum. Genet. 37, 482–498 (1985). 20. Vandenplas, S. et al. J. med. Genet. 21, 164–172 (1984). 21. Feinberg, A. P. & Vogelstein, B. Analyt. Biochem. 137, 266–267 (1984). 22. Church, G. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 81, 1991–1995 (1984). 23. Telenius–Berg, M. et al. Eur. J. din. Invest. 7, 7–16 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mathew, C., Chin, K., Easton, D. et al. A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. Nature 328, 527–528 (1987). https://doi.org/10.1038/328527a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/328527a0
- Springer Nature Limited
This article is cited by
-
MEN 2A-related cutaneous lichen amyloidosis: report of three kindred and systematic literature review of clinical, biochemical and molecular characteristics
Familial Cancer (2016)
-
Metastatic Medullary Carcinoma of Thyroid Presenting as a Dural-Based Mass: Case Report and Review of Literature
Endocrine Pathology (2013)
-
Management of medullary thyroid carcinoma and MEN2 syndromes in childhood
Nature Reviews Endocrinology (2011)