Skip to main content
Log in

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. 1. Rail, W. & Sutherland, R. J. / Am. chem. Soc. 79, 3608 (1957). 2. Siegelbaum, S. A. & Tsien, R. W. Trends Neurosci. 6, 307–313 (1983). 3. Kennedy, M. B. A. Rev. Neurosci. 6, 493–525 (1983). 4. Nestler, E..J. & Greengard, p. Nature 305, 583–588 (1983). 5. Paupardin–Tritsch, D., Hammohd, C., Gerschenfeld, H. M., Nairn, A. C. & Greengard, P. 29. Nature 323, 812–814 (1986). 6. Rasmussen, H. & Barrett, P. Physiol. Rev. 64, 938–984 (1984). 31. 7. De Riemer, S. A., Strong, J. A., Albert, K. A., Greengard, P. & Kaczmarek, L. Nature 313, 313–316 (1985). 8. Rane, S. G. & Dunlap, K. Proc. natn. Acad. ScL U.S.A. 83, 184–188 (1986). 9. Higashida, H. & Brown, D. A. Nature 323, 333–335 (1986). 10. Hammond, C., Paupardin–Tritsch, D., Nairn, A. C., Greengard, P. & Gerschenfeld, H. M. 35. Nature 325, 809–811 (1987). 11. Fisher, S. K. & Agranoff, B. W. J. Neurochem. 48, 909–1017 (1987). 12. Gilman, A. G. Cell 36, 577–579 (1984). 13. Pfaffinger, P., Martin, J., Hunter, D., Nathanson, N. & Hille, B. Nature 317, 536–538 (1985). 14. Breitweiser, G. & Szabo, G. Nature 317, 538–540 (1985). 15. Logothetis, D. E., Kurachi, Y., Galper, J., Neer, E. J. & Clapham, D. E. Nature 325, 321–326 41. (1987). . 16. Yatani, A., Codina, J., Brown, A. M. & Birnbaumer, L. Science 235, 207–211 (1987). 17. Needleman, P., Turk, J., Jakschick, B. A., Morrison, A. R. & Lefkowith, J. B. A. Rev. Biochem. 55, 69–102 {1986). 18. Samuelsson, E. Biochem. biophys. Acta 84, 218–219 (1964). 19. Sautebin, L., Spagnuolo, C., Galli, C. & Galli, G. Prostaglandins 16, 985–988 (1978). 20. Wolfe, L. S. J. Neurochem. 38, 1–14 (1982). 21. Lindgren, J. A., Hokfelt, T., Dahlen, S. E., Patrono, C. & Samuelsson, B. Proc. natn. Acad. Sci U.S.A. 81, 6212–6216 (1984). 22. Shimizu, T., Takusagawa, Y., Izumi, T., Ohishi, N. & Seyama, Y. / Neurochem. 48, 1541–1546 (1987). 23. Jelsema, C. L. & Axelrod, J. Proc. natn. Acad. Sci U.S.A. 84 (in the press). 24. Kandel, E. R. & Schwartz, J. H. Science 218, 433–443 (1982). 25. Klein, M., Camardo, J. S. & Kandel, E. R. Proc. natn. Acad, ScL US. A 79,5713–5717 (1982). 26. Siegelbaum, S. A., Camardo, J. S. & Kandel, E. R. Nature 299, 413–417 (1982). 27. Shuster, M. J:, Camardo, J. S., Siegelbaum, S. A. & Kandel, E. R. Nature 313,392–395 (1985). 28. Abrams, T. W., Castellucci, V. R, Camardo, J. S., Kandel, E. R. & Lloyd, P. E. Proc. natn. Acad. Sci. U.S.A. 81, 7956–7960 (1984). 29. Ocorr, K. A. & Byrne, J. H. Neurosci. Lett. 55, 113–118 (1985). 30. Brezina, V., Eckert, R. & Erxleben, C. /. Physiol., Lond. 382, 267–290 (1987). 31. Colombaioni, L., Paupardin–Tritsch, D., Vidal, P. P. & Gerschenfeld, H. M. J. Neurosci. 5, 2533–2538 (1985). 32. Ruben, P., Johnson, J. W. & Thompson, S. J. Neurosci. 6, 252–259 (1986). 33. Gottrell, G. A., Davies, N. W. & Green, K. A. /. Physiol, Lond. 356, 315–333 (1984). 34. Belardetti, R, Kandel, E. R. & Siegelbaum, S. A. Nature 325; 153–156 (1987). 35. Piomelli, D., Shapiro, E., Feinmark, S. J. & Schwartz, J. H. J. Neurosci (in the press). Kretz, R., Shapiro, E. & Kandel, E. R. J. Neurophysiol 55, 131–146 (1986). Choi, D. W. & Fischbach, G. D. / Neurophysiol. 45, 605–620 (1981). 38. Rayport, S. & Schacher, S. J. /. Neurosci. 6, 759–763 (1985). 39. Van den Bosch, H. Biochem. biophys. Acta 604, 191–246 (1980). 40. Irvine, R. R Biochem. J. 204, 3–16 (i982). 41. Flower, R. J. Br. med. Bull. 39, 260–264 (1983). 42. Shen, T. Y. & Winter, C. A. Adv. Drug. Res. 56, 665–675 (1977). 43. Egan, R. W. & Gale, P. H. in Prostaglandins, Leukotrienes and Lipoxins (ed. Bailey, J. M.) 593–607 (Plenum, New York, 1984), 44. Robison, G. A., Butcher, R. W. & Sutherland, E. W. Cyclic AMP (Academic, New York, 1971). 45. Kretz, R., Shapiro, E. & Kandel, E. R. /. Neurophysiol. 55, 113–130 (1986). 46. Dunlap, K. & Fischbach, G. D. Nature 276, 837–838 (1978). 47. Mudge, A., Leeman, S. & Fischbach, G. D. Proc. natn. Acad. Sci. U.S.A. 76, 526–530 (1979). 48. Hedqvist, P. A. Rev. Pharmac. Tax. 17, 259–279 (1977). 49. Wigstrom, H., Gustafson, B., Huang, Y–Y. & Abraham, W. D. Acta–physioL Scand. 126, 317–319 (1986). 50.Bliss, T. V. P., Douglas, R. M., Errington, M. C. & Lynch, M. A. /. Physiol., Lond. 377, 391–408 (1986).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Piomelli, D., Volterra, A., Dale, N. et al. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature 328, 38–43 (1987). https://doi.org/10.1038/328038a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/328038a0

  • Springer Nature Limited

This article is cited by

Navigation