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A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes

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Abstract

Cloned blood lymphocytes that do not express the α- and β-chains of the T-cell receptor show MHC-unrestricted cytotoxicity. These cells carry the γ-protein, disulphide-linked either to another molecule or to itself, and associated with the CD3 complex. These observations may help to solve the mystery posed by the discovery of the γ gene.

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Authors and Affiliations

  1. The Netherlands Cancer Institute, Department of Immunology, Amsterdam, The Netherlands

    Jannie Borst, Johan W. van Oostveen & Cornelis J. Melief

  2. Rotterdam Radiotherapeutic Institute, Department of Immunology, Groene Hilledijk 30, 3075 EA, Rotterdam, The Netherlands

    René J. van de Griend & Reinder L. H. Bolhuis

  3. Harvard Medical School, Department of Genetics, Boston, Massachusetts, USA

    Siew-Lan Ang & J. G. Seidman

  4. Radiobiological Institute TNO, Department of Immunology, Rijswijk, The Netherlands

    Reinder L. H. Bolhuis

Authors
  1. Jannie Borst
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  2. René J. van de Griend
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  3. Johan W. van Oostveen
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  4. Siew-Lan Ang
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  5. Cornelis J. Melief
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  6. J. G. Seidman
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  7. Reinder L. H. Bolhuis
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Borst, J., van de Griend, R., van Oostveen, J. et al. A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes. Nature 325, 683–688 (1987). https://doi.org/10.1038/325683a0

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  • DOI: https://doi.org/10.1038/325683a0

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