Abstract
A number of agents that mimic the ability of the thryoid hormone, T3, to decrease plasma cholesterol levels are described; one is as effective as T3 at reducing cholesterol levels and stimulating liver function, but has very little effect on cardiac function and is thus less likely to be toxic. The agent may be useful in the treatment of atherosclerosis.
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Underwood, A., Emmett, J., Ellis, D. et al. A thyromimetic that decreases plasma cholesterol levels without increasing cardiac activity. Nature 324, 425–429 (1986). https://doi.org/10.1038/324425a0
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DOI: https://doi.org/10.1038/324425a0
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