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Synthetic ligands point to cell surface strategies

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Abstract

Protein shedding, the proteolytic release of a cell surface protein, can serve a regulatory role by liberating soluble molecules into circulation while decreasing their concentration on the cell surface1. We have created a new class of multivalent ligands, ‘neoglycopolymers’, which are designed to promote the proteolytic cleavage of a cell adhesion molecule involved in the inflammatory response, L-selectin2. These synthetic ligands induce the release of the extracellular portion of L-selectin by appropriating an endogenous protease; such activities suggest new strategies to generate anti-inflammatory agents and regulate the cell surface.

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Figure 1: Effects of neoglycopolymer on human neutrophils.

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Authors and Affiliations

  1. Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, Madison, 53706, Wisconsin, USA

    Eva J. Gordon, William J. Sanders & Laura L. Kiessling

Authors
  1. Eva J. Gordon
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  2. William J. Sanders
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  3. Laura L. Kiessling
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Gordon, E., Sanders, W. & Kiessling, L. Synthetic ligands point to cell surface strategies. Nature 392, 30–31 (1998). https://doi.org/10.1038/32073

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