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Transfer of specificity by murine α and β T-cell receptor genes

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Abstract

T-cell receptor α- and β-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity. Expression of the transfected α- and β genes endowed the recipient cell with the specificity of the donor cell.

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Authors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005, Basel, Switzerland

    Zlatko DembiĆ, Werner Haas, Siegfried Weiss, James McCubrey, Hansruedi Kiefer, Harald von Boehmer & Michael Steinmetz

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  1. Zlatko DembiĆ
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  2. Werner Haas
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  3. Siegfried Weiss
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  4. James McCubrey
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  5. Hansruedi Kiefer
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  6. Harald von Boehmer
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  7. Michael Steinmetz
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DembiĆ, Z., Haas, W., Weiss, S. et al. Transfer of specificity by murine α and β T-cell receptor genes. Nature 320, 232–238 (1986). https://doi.org/10.1038/320232a0

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