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Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III

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Abstract

The level of synthesis of viral proteins and heterologous proteins under the control of long terminal repeat sequences of human T-lymphotropic virus type HI (HTLV-III or LAV) increases dramatically in cells that constitutively express the HTLV-III trans-activator protein. Increased levels of protein synthesis occur without a comparable increase in the levels of corresponding messenger RNA. We propose that post-transcriptional events mediated by the HTLV-III trans-activator protein account for positive regulation of HTLV-III gene products in infected cells.

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Authors and Affiliations

  1. Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts, 01225, USA

    Craig A. Rosen, Joseph G. Sodroski, Wei Chun Goh, Andrew I. Dayton, Judith Lippke & William A. Haseltine

  2. Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts, 02115, USA

    William A. Haseltine

Authors
  1. Craig A. Rosen
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  2. Joseph G. Sodroski
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  3. Wei Chun Goh
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  4. Andrew I. Dayton
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  5. Judith Lippke
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  6. William A. Haseltine
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Rosen, C., Sodroski, J., Goh, W. et al. Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III. Nature 319, 555–559 (1986). https://doi.org/10.1038/319555a0

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