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Expression of the c-myb proto-oncogene during cellular proliferation

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Abstract

In several cell types, messenger RNA levels of the nuclear proto-oncogene c-myb vary as a function of cellular proliferation ; a transient increase in c-myb steady-state mRNA, mediated by post-transcriptional mechanisms, occurs during cell-cycle progression. In contrast, both quiescent and proliferating immature thymocytes contain exceptionally high levels of c-myb mRNA as a consequence of increased c-myb transcription.

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Author notes

  1. Craig B. Thompson and Paul E. Neiman: Department of Medicine, University of Washington, Seattle, Washington 98195, USA

  2. Mark Groudine: Department of Radiation Oncology, University of Washington, Seattle, Washington 98195, USA

Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington, 98104, USA

    Craig B. Thompson, Peter B. Challoner, Paul E. Neiman & Mark Groudine

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  1. Craig B. Thompson
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  2. Peter B. Challoner
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  3. Paul E. Neiman
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Thompson, C., Challoner, P., Neiman, P. et al. Expression of the c-myb proto-oncogene during cellular proliferation. Nature 319, 374–380 (1986). https://doi.org/10.1038/319374a0

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