Abstract
Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the β-Cells of the endocrine pancreas of transgenic mice. The α- and δ-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized β-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes.
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Hanahan, D. Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315, 115–122 (1985). https://doi.org/10.1038/315115a0
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DOI: https://doi.org/10.1038/315115a0
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