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Segmental distribution of bithorax complex proteins during Drosophila development

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Abstract

The Ubx and bxd transcription units comprise a single functional domain in the bithorax complex of Drosophila melanogaster. The segmental distributions and nuclear localization of proteins encoded by the Ubx unit have been determined by immunofluorescence staining with antibodies raised against a fusion protein containing Ubx coding sequences. Wild-type and mutant distributions are consistent with a model in which the protein-coding functions of the domain derive from the Ubx unit and are regulated by the bxd unit.

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Authors and Affiliations

  1. Department of Biochemistry, Stanford University School of Medicine, Stanford, California, 94305, USA

    Philip A. Beachy & David S. Hogness

  2. Department of Biological Sciences, Stanford University School of Medicine, Stanford, California, 94305, USA

    Stephen L. Helfand

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  1. Philip A. Beachy
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  2. Stephen L. Helfand
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  3. David S. Hogness
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Beachy, P., Helfand, S. & Hogness, D. Segmental distribution of bithorax complex proteins during Drosophila development. Nature 313, 545–551 (1985). https://doi.org/10.1038/313545a0

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