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The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

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Abstract

A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.

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Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Alan L. Schechter, David F. Stern, Lalitha Vaidyanathan & Robert A. Weinberg

  2. The Rockefeller University, New York, New York, USA

    Stuart J. Decker

  3. Department of Pathology, Harvard Medical School, 25 Shattuck St, Boston, Massachusetts, 02115, USA

    Jeffrey A. Drebin & Mark I. Greene

Authors
  1. Alan L. Schechter
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  2. David F. Stern
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  3. Lalitha Vaidyanathan
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  4. Stuart J. Decker
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  5. Jeffrey A. Drebin
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  6. Mark I. Greene
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  7. Robert A. Weinberg
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Schechter, A., Stern, D., Vaidyanathan, L. et al. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature 312, 513–516 (1984). https://doi.org/10.1038/312513a0

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  • DOI: https://doi.org/10.1038/312513a0

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