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Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

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Abstract

The most JH-proximal VH gene segments are used highly preferentially to form VHDJH rearrangements in pre-B-cell lines. This result demonstrates that the rate at which immunoglobulin VH gene segments recombine is influenced by their chromosomal organization, and that the initial repertoire ofVH genes expressed in pre-B cells is strikingly different from that seen in mature populations.

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Authors and Affiliations

  1. Department of Biochemistry and Institute for Cancer Research, Columbia University, College of Physicians and Surgeons, New York, 10032, USA

    George D. Yancopoulos & Frederick W. Alt

  2. Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Stephen V. Desiderio, Michael Paskind & David Baltimore

  3. Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Stephen V. Desiderio, Michael Paskind & David Baltimore

  4. The Cellular Immunobiology Unit of the Tumor Institute, Departments of Microbiology and The Comprehensive Cancer Care Center, University of Alabama, Birmingham, Alabama, 35294, USA

    John F. Kearney

Authors
  1. George D. Yancopoulos
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  2. Stephen V. Desiderio
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  3. Michael Paskind
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  4. John F. Kearney
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  5. David Baltimore
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  6. Frederick W. Alt
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Yancopoulos, G., Desiderio, S., Paskind, M. et al. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 311, 727–733 (1984). https://doi.org/10.1038/311727a0

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  • DOI: https://doi.org/10.1038/311727a0

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