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Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

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Abstract

We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.

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Authors and Affiliations

  1. Metabolism Branch, National Cancer Institute, Bethesda, Maryland, 20205, USA

    Warren J. Leonard, Joel M. Depper, Martin Krönke, Penny B. Svetlik, Nancy J. Peffer, Thomas A. Waldmann & Warner C. Greene

  2. Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, 20205, USA

    Gerald R. Crabtree

  3. Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland, 20205, USA

    Stuart Rudikoff & Janet Pumphrey

  4. E.I. du Pont, de Nemours and Co., Glenolden, Philadelphia, 19036, USA

    Richard J. Robb

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  1. Warren J. Leonard
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  2. Joel M. Depper
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  4. Stuart Rudikoff
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  5. Janet Pumphrey
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  6. Richard J. Robb
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  7. Martin Krönke
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  8. Penny B. Svetlik
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  9. Nancy J. Peffer
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  10. Thomas A. Waldmann
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  11. Warner C. Greene
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Leonard, W., Depper, J., Crabtree, G. et al. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311, 626–631 (1984). https://doi.org/10.1038/311626a0

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  • DOI: https://doi.org/10.1038/311626a0

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