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Structure of the nucleosome core particle at 7 Å resolution

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Abstract

The crystal structure of the nucleosome core particle has been solved to 7 Å resolution. The right-handed B-DNA superhelix on the outside contains several sharp bends and makes numerous interactions with the histone octamer within. The central turn of superhelix and H3 · H4 tetramer have dyad symmetry, but the H2A · H2B dimers show departures due to interparticle associations.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, University Postgraduate Medical School, Hills Road, Cambridge, CB2 2QH, UK

    T. J. Richmond, J. T. Finch, B. Rushton, D. Rhodes & A. Klug

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  1. T. J. Richmond
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  2. J. T. Finch
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  3. B. Rushton
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  4. D. Rhodes
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  5. A. Klug
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Richmond, T., Finch, J., Rushton, B. et al. Structure of the nucleosome core particle at 7 Å resolution. Nature 311, 532–537 (1984). https://doi.org/10.1038/311532a0

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  • DOI: https://doi.org/10.1038/311532a0

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