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Human large granular lymphocytes are potent producers of interleukin-1

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Abstract

Natural killer (NK) activity1 against tumour and virus-infected target cells is shown by a subpopulation of peripheral blood mononuclear leukocytes with the morphological features of large granular lymphocytes (LGL)2. The lineage of human LGL is still controversial, as they display surface markers of both T lymphocytes and myelomonocytic cells3. LGL have recently been reported to produce lymphokines such as interleukin-2 (IL-2)4,5 and α- as well as γ-interferons6, functions associated mainly with T cells. To determine whether cytokines associated with other cell lineages are also produced by LGL, we examined whether they might produce a myelomonocyte-associated cytokine such as interleukin-1 (IL-1). IL-1 is a 12–18,000 molecular weight (MW) lymphokine produced by a variety of cell types such as monocytes7, keratinocytes8 and a human dendritic cell line9, which plays a crucial role in immunoregulation and inflammation10,11. Moreover, IL-1 has recently been reported to act synergistically with IL-2 and interferons in boosting LGL-mediated NK activity12. We now show that a subset of highly purified human LGL with NK activity can be stimulated to secrete a soluble factor with the biochemical and biological characteristics of human IL-1.

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Author notes

  1. Giuseppe Scala

    Present address: Institute of Biological Chemistry, 2nd University Medical School, via S. Pansini 5, Naples, Italy

Authors and Affiliations

  1. Laboratory of Molecular Immunoregulation, National Cancer Institute–Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Giuseppe Scala & Joost J. Oppenheim

  2. Biological Therapeutics Branch, Biological Response Modifiers Program, National Cancer Institute–Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Paola Allavena, John R. Ortaldo & Ronald B. Herberman

  3. Office of Biologics, National Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland, 20205, USA

    Julie Y. Djeu

  4. Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Tadashi Kasahara

Authors
  1. Giuseppe Scala
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  2. Paola Allavena
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  3. Julie Y. Djeu
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  4. Tadashi Kasahara
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  5. John R. Ortaldo
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  6. Ronald B. Herberman
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  7. Joost J. Oppenheim
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Scala, G., Allavena, P., Djeu, J. et al. Human large granular lymphocytes are potent producers of interleukin-1. Nature 309, 56–59 (1984). https://doi.org/10.1038/309056a0

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  • DOI: https://doi.org/10.1038/309056a0

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