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Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

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Abstract

Deletion experiments have defined two stretches of DNA (genetic elements), lying close to the promoter for a human gene for metallothionein, that separately mediate the induction of the gene by heavy metal ions, particularly cadmium, and by glucocorticoid hormones. The element responsible for induction by cadmium is duplicated, yet a single copy is fully functional; the element responsible for induction by glucocorticoid hormones is coincident with the DNA-binding site for the glucocorticoid hormone receptor.

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Authors and Affiliations

  1. Department of Microbiology, University of Southern California School of Medicine, Los Angeles, California, 90033, USA

    Michael Karin, Alois Haslinger & Heidi Holtgreve

  2. Department of Genetics, Research School of Biological Sciences, Australian National University, Canberra, ACT, 2601, Australia

    Robert I. Richards

  3. Physiological Chemistry Institute, Philipps University, 3550, Marburg, West Germany

    Paul Krauter, Hannes M. Westphal & Miguel Beato

Authors
  1. Michael Karin
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  2. Alois Haslinger
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  3. Heidi Holtgreve
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  4. Robert I. Richards
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  5. Paul Krauter
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  6. Hannes M. Westphal
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  7. Miguel Beato
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Karin, M., Haslinger, A., Holtgreve, H. et al. Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature 308, 513–519 (1984). https://doi.org/10.1038/308513a0

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  • DOI: https://doi.org/10.1038/308513a0

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