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Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

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Abstract

Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region of the genome that has rearranged in a T-cell lymphoma and several T-cell hybridomas. These characteristics suggest that it encodes one chain of the elusive antigen receptor on the surface of T lymphocytes.

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Author information

Author notes

  1. Stephen M. Hedrick

    Present address: Department of Biology, University of California at San Diego, La Jolla, California, 92093, USA

  2. Mark M. Davis

    Present address: Stanford University School of Medicine,

Authors and Affiliations

  1. Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Stephen M. Hedrick, David I. Cohen, Ellen A. Nielsen & Mark M. Davis

  2. Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California, 94305, USA

    David I. Cohen & Mark M. Davis

Authors
  1. Stephen M. Hedrick
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  2. David I. Cohen
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  3. Ellen A. Nielsen
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  4. Mark M. Davis
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Hedrick, S., Cohen, D., Nielsen, E. et al. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308, 149–153 (1984). https://doi.org/10.1038/308149a0

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