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Essential requirement for major histocompatibility complex recognition in T-cell tolerance induction

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Abstract

The induction of T-cell responses involves the recognition of extrinsic antigen in association with antigens of the major histocompatibility complex (MHC), in mice and man, with different T cells recognizing antigen in association with either class I (H–2K/D, HLA-A, B, C) or class II (Ia, HLA-D/DR) MHC antigens1–5. However, the requirement of MHC recognition in the induction of immunological tolerance remains ill defined. With human T helper clones recognizing synthetic peptides of influenza haemagglutinin (HA-1), we have investigated the nature of antigen-induced stimulation6, and antigen-induced antigen-specific unresponsiveness, immunological tolerance7. Tolerance is not due to cell death, as the cells remain responsive to interleukin-2 and is associated with the loss of T3 antigen from the cell surface8. Using monoclonal antibodies to the non-polymorphic regions of human class II antigens to inhibit the induction of T-cell tolerance we report here that induction of tolerance requires the recognition of MHC antigens.

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Human Tumour Immunology Group, University College Hospital, Faculty of Clinical Sciences, University Street, London, WC1E 6JJ, UK

    Jonathan R. Lamb

  2. Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, Gower Street, London, WC1E 6BT, UK

    Marc Feldmann

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  1. Jonathan R. Lamb
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  2. Marc Feldmann
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Lamb, J., Feldmann, M. Essential requirement for major histocompatibility complex recognition in T-cell tolerance induction. Nature 308, 72–74 (1984). https://doi.org/10.1038/308072a0

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