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Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus

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Abstract

A tissue-specific transcriptional enhancer element that is associated with the human immunoglobulin heavy-chain locus is defined. In a non-Hodgkin's lymphoma that contains a translocated c-myc gene this enhancer is retained on the 14q+ chromosome and occurs within sequences shown to activate previously cryptic promoters of the c-myc gene.

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Authors and Affiliations

  1. Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Adrian C. Hayday, Stephen D. Gillies, Haruo Saito, Charles Wood & Susumu Tonegawa

  2. Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    Klas Wiman & William S. Hayward

Authors
  1. Adrian C. Hayday
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  2. Stephen D. Gillies
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  3. Haruo Saito
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  4. Charles Wood
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  5. Klas Wiman
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  6. William S. Hayward
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  7. Susumu Tonegawa
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Hayday, A., Gillies, S., Saito, H. et al. Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus. Nature 307, 334–340 (1984). https://doi.org/10.1038/307334a0

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  • DOI: https://doi.org/10.1038/307334a0

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