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Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1

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Abstract

Myelin-associated glycoprotein (MAG) is a quantitatively minor component in both peripheral and central myelin sheaths that is thought to have a role in cell–cell interactions within the nervous system1. We show here that a mouse monoclonal antibody, HNK-1, which is directed against human natural killer cells also recognizes an antigenic determinant of human central and peripheral nervous system white matter by immunoperoxidase staining of tissue sections. Immunoblot analysis of myelin proteins and purified extracted MAG indicates that the antigen recognized is MAG.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, K7L 3N6, Canada

    R. C. McGarry & J. C Roder

  2. Department of Biological Sciences, Stanford University, Stanford, California, 94305, USA

    S. L. Helfand

  3. Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20014, USA

    R. H. Quarles

Authors
  1. R. C. McGarry
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  2. S. L. Helfand
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  3. R. H. Quarles
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  4. J. C Roder
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McGarry, R., Helfand, S., Quarles, R. et al. Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1. Nature 306, 376–378 (1983). https://doi.org/10.1038/306376a0

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  • DOI: https://doi.org/10.1038/306376a0

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