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Sex reversal in XY mice caused by dominant mutation on chromosome 17

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Abstract

A Y-linked gene(s) is undoubtedly a prerequisite for testicular development in mammals. However, exceptional cases suggest that the mere presence of the Y chromosome or the Y-linked testis-determining gene does not totally control the fate of the bipotential gonad1. For example, in the mouse, a major as yet unmapped autosomal locus is necessary for normal testicular development and at least one additional autosomal locus is implicated2. We present here a third autosomal sex-determining locus. This dominantly inherited trait, tentatively named T-associated sex reversal (gene symbol Tas), is closely linked to or a part of the T/t complex on chromosome 17 of the mouse. Gonads of chromosomally XY individuals who inherit Tas on the C57BL/6J inbred strain background differentiate as ovaries or ovotestes.

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References

  1. Lyon, M. F., Cattanach, B. M. & Charlton, H. M. in Mechanisms of Sex Determination in Animals and Man (eds Austin, C. R. & Edwards, R. G.) 329–386 (Academic, New York, 1981).

    Google Scholar 

  2. Eicher, E. M. in Prospects for Sexing Mammalian Sperm (eds Amann, R. P. & Seidel, G. E. Jr) 121–135 (Colorado Associated University Press, Boulder, 1982).

    Google Scholar 

  3. Dickie, M. M. Mouse News Lett. 32, 43–44 (1965).

    Google Scholar 

  4. Bennett, D. B. Cell 6, 441–454 (1975).

    Article  Google Scholar 

  5. Johnson, D. R. Genetics 76, 795–805 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Johnson, D. R. Genet. Res. Camb. 24, 207–213 (1975).

    Article  Google Scholar 

  7. Eicher, E. M., Beamer, W. G., Washburn, L. L. & Whitten, W. K. Cytogenet. Cell Genet. 28, 104–115 (1980).

    Article  CAS  Google Scholar 

  8. Eicher, E. M., Washburn, L. L., Whitney, J. B. III & Morrow, K. E. Science 217, 535–537 (1982).

    Article  ADS  CAS  Google Scholar 

  9. Babiarz, B., Garrisi, G. T. & Bennett, D. Genet. Res. Camb. 39, 111–120 (1982).

    Article  CAS  Google Scholar 

  10. Simpson, J. L. Disorders of Sexual Differentiation, 141–155 (Academic, New York, 1976).

    Google Scholar 

  11. Ohno, S. Monogr. Endocr. 11, 91 (1979).

    Article  Google Scholar 

  12. Forejt, J. & Iványe, P. Genet. Res. Camb. 24, 189–206 (1975).

    Article  Google Scholar 

  13. Hammerberg, C. Genet. Res. Camb. 27, 71–77 (1981).

    Article  Google Scholar 

  14. Theiler, K. The House Mouse, 100–104 (Springer, New York, 1972).

    Google Scholar 

  15. Simpson, E., Chandler, P., Washburn, L. L., Bunker, H. P. & Eicher, E. M. Differentiation (in the press).

  16. Whitten, W. K., Beamer, W. G. & Byskov, A. G. J. Embryol exp. Morph. 52, 63–78 (1979).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, Maine, 04609, USA

    Linda L. Washburn & Eva M. Eicher

Authors
  1. Linda L. Washburn
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  2. Eva M. Eicher
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Washburn, L., Eicher, E. Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature 303, 338–340 (1983). https://doi.org/10.1038/303338a0

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  • DOI: https://doi.org/10.1038/303338a0

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