Abstract
Calcium channels in excitable membranes are of great importance for many cellular functions. Modulation of these channels by neurotransmitters and drugs regulates calcium influx into the cell and thereby alters the functional state of the cell. Recently it has become possible to measure properties of single calcium channels directly and to obtain evidence on mechanisms of their modulation.
Similar content being viewed by others
References
Ebashi, S. & Endo, M. Prog. Biophys. molec. Biol. 18, 123–128 (1968).
Allen, D. G. & Kurihara, S. Eur. Heart J. 1, Suppl. A, 5–15 (1980).
Katz, B. The Release of Neural Transmitter Substances (Liverpool University Press, 1969).
Baker, P. F. & Knight, D. E. Phil. Trans. R. Soc. B296, 83–103 (1981).
Cohen, P. Nature 296, 613–620 (1982).
Meech, R. W. A. Rev. Biophys. Bioengng 7, 1–18 (1978).
Colquhoun, D., Neher, E., Reuter, H. & Stevens, C. F. Nature 294, 752–754 (1981).
Maruyama, Y. & Petersen, O. H. Nature 300, 61–63 (1982).
Lee, K. S., Akaike, N. & Brown, A. M. J. Neurosci. Meth. 2, 51–78 (1980).
Kostyuk, P. G., Krishtal, O. A. & Pidoplichko, V. I. J. Neurosci. Meth. 4, 201–210 (1981).
Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. Pflügers Arch. ges. Physiol. 391, 85–100 (1981).
Berridge, M. J. Handbk exp. Pharmac. 58 Pt II 227–270 (1982).
Schatzmann, H. J. in Membranes and Transport Vol. 1 (ed. Martonosi, A.) 601–605 (Plenum, New York, 1982).
Reuter, H. in Membranes and Transport Vol. 1 (ed. Martonosi, A.) 623–631 (Plenum, New York, 1982).
Reuter, H. Prog. Biophys. molec. Biol. 26, 1–43 (1973).
Brown, A. M., Akaike, N. & Lee, K. S. Ann. N.Y. Acad. Sci. 307, 330–344 (1978).
Hagiwara, S. & Byerly, L. A. Rev. Neurosci. 4, 69–125 (1981).
Kostyuk, P. G. Biochim. biophys. Acta 650, 128–150 (1981).
Almers, W. Rev. Physiol. Biochem. Pharmac. 82, 96–190 (1978).
Adams, D. J. & Gage, P. W. Science 192, 783–784 (1976).
Kostyuk, P. G., Krishtal, O. A. & Pidoplichko, V. I. J. Physiol., Lond. 310, 403–421 (1981).
Fenwick, E. M., Marty, A. & Neher, E. J. Physiol., Lond. 331, 599–635 (1982).
Reuter, H. & Scholz, H. J. Physiol., Lond. 264, 17–47 (1977).
Adams, D. J., Smith, S. J. & Thompson, S. H. A. Rev. Neurosci. 3, 141–167 (1980).
Lee, K. S. & Tsien, R. W. Nature 297, 498–501 (1982).
Garnier, D., Rougier, O., Gargouil, M. & Coraboeuf, E. Pflügers Arch. ges. Physiol. 313, 321–342 (1969).
Kostyuk, P. G. & Krishtal, O. A. J. Physiol., Lond. 270, 545–568 (1977).
Hille, B. J. J. gen. Physiol. 58, 599–619 (1971).
Reuter, H. A. Rev. Physiol. 41, 413–424 (1979).
Tillotson, D. Proc. natn. Acad. Sci. U.S.A. 76, 1497–1500 (1979).
Ashcroft, F. M. & Stanfield, P. R. J. Physiol., Lond. 330, 349–372 (1982).
Standen, N. B. Nature 293, 158–159 (1981).
Eckert, R. & Tillotson, D. L. J. Physiol., Lond. 314, 265–280 (1981).
Lux, H. D. & Nagy, K. Pflügers Arch. ges. Physiol. 391, 252–254 (1981).
Reuter, H., Stevens, C. F., Tsien, R. W. & Yellen, G. Nature 297, 501–504 (1982).
Akaike, N., Fishman, H. M., Lee, K. S., Moore, L. E. & Brown, A. M. Nature 274, 379–382 (1978).
Krishtal, O. A., Pidoplichko, V. I. & Shakhovalov, Y. A. J. Physiol., Lond. 310, 423–434 (1981).
Brown, A. M., Camerer, H., Kunze, D. L. & Lux, H. D. Nature 299, 156–158 (1982).
Almers, W., Fink, R. & Palade, P. T. J. Physiol., Lond. 312, 177–207 (1981).
Reuter, H. in The Slow Inward Current and Cardiac Arrhythmias (eds Zipes, D. P., Bailey, J. C. & Elharrar, V.) 205–219 (Martinus Nijhoff, The Hague, 1980).
Tsien, R. W. & Siegelbaum, S. in Physiology of Membrane Disorders (eds Andreoli, T. E., Hoffman, J. F. & Fanestil, D. D.) 517–538 (Plenum, New York, 1978).
Reuter, H. J. Physiol., Lond. 192, 479–492 (1967).
Reuter, H. J. Physiol., Lond. 242, 429–451 (1974).
Reuter, H. & Scholz, H. J. Physiol., Lond. 264, 49–62 (1977).
Pappano, A. J. & Carmeliet, E. E. Pflügers Arch. ges. Physiol. 382, 17–26 (1979).
Kass, R. A. & Wiegers, S. E. J. Physiol., Lond. 322, 541–558 (1982).
Noma, A., Kotake, H. & Irisawa, H. Pflügers Arch. ges. Physiol. 388, 1–9 (1980).
Vassort, G. et al. Pflügers Arch. ges. Physiol. 309, 70–81 (1969).
Brown, H. F., McNaughton, P. A., Noble, D. & Noble, S. J. Phil. Trans. R. Soc. B270, 527–537 (1975).
Morad, M., Sander, C. & Weiss, J. J. Physiol., Lond. 311, 585–604 (1981).
Niedergerke, R. & Page, S. Proc. R. Soc. B197, 333–362 (1977).
Tsien, R. W. Nature new Biol. 245, 120–122 (1973).
Trautwein, W., Taniguchi, J. & Noma, A. Pflügers Arch. ges. Physiol. 392, 307–314 (1982).
Tsien, R. W., Giles, W. & Greengard, P. Nature new Biol. 240, 181–183 (1972).
Osterrieder, W. et al. Nature 298, 576–578 (1982).
Tsien, R. W. Adv. Cyclic Nucleotide Res. 8, 363–420 (1977).
Rinaldi, M. L., Le Peuch, C. J. & Demaille, J. G. FEBS Lett. 129, 277–281 (1981).
Johnson, C. L. & Mizoguchi, H. J. Pharmac. exp. Ther. 200, 174–186 (1977).
Sanchez-Chapula, J. Eur. J. Pharmac. 74, 253–256 (1981).
Eckel, L., Gristwood, R. W., Nawrath, H., Owen, D. A. A. & Satter, P. J. Physiol., Lond. 330, 111–123 (1982).
Weingart, R., Kass, R. S. & Tsien, R. W. Nature 273, 389–392 (1978).
Marban, E. & Tsien, R. W. J. Physiol., Lond. 329, 589–614 (1982).
Watanabe, A. M. & Besch, H. R. Circulation Res. 35, 316–324 (1974).
Giles, W. & Noble, S. J. J. Physiol., Lond. 261, 103–123 (1976).
Hino, N. & Ochi, R. J. Physiol., Lond. 307, 183–197 (1980).
Biegon, R. L., Epstein, P. M. & Pappano, A. J. J. Pharmac. exp. Ther. 215, 348–356 (1980).
Byerly, L. & Hagiwara, S. J. Physiol., Lond. 322, 503–528 (1982).
Yatani, A., Tsuda, Y., Akaike, N. & Brown, A. M. Nature 296, 169–171 (1982).
Kostyuk, P. G., Veselovsky, N. S. & Fedulova, S. A. Neuroscience 6, 2431–2437 (1981).
Klein, M. & Kandel, E. R. Proc. natn. Acad. Sci. U.S.A. 75, 3512–3516 (1978).
Shapiro, E., Castellucci, V. F. & Kandel, E. R. Proc. natn. Acad. Sci. U.S.A. 77, 629–633 (1980).
Klein, M., Camardo, J. & Kandel, E. R. Proc. natn. Acad. Sci. U.S.A. 79, 5713–5717 (1982).
Siegelbaum, S., Camardo, J. S. & Kandel, E. R. Nature 299, 413–417 (1982).
Kuba, E., Kato, E., Kumamoto, E., Koketsu, K. & Hirai, K. Nature 291, 654–656 (1981).
Jakobs, K. H. Molec. cell. Endocr. 16, 147–156 (1979).
Horn, J. P. & McAfee, D. J. Physiol., Lond. 301, 191–204 (1980).
Dunlap, K. & Fischbach, G. D. Nature 276, 837–839 (1978).
Dunlap, K. & Fischbach, G. D. J. Physiol., Lond. 317, 519–535 (1981).
Galvan, M. & Adams, P. R. Brain Res. 244, 135–144 (1982).
Langer, S. Z. Br. J. Pharmac. 60, 481–497 (1977).
Starke, K. A. Rev. Pharmac. Tox. 21, 7–30 (1981).
Shapiro, E., Castellucci, V. F. & Kandel, E. R. Proc. natn. Acad. Sci. U.S.A. 77, 1185–1189 (1980).
Armstrong, C. M., Bezanilla, F. M. & Horowicz, P. Biochim. biophys. Acta 267, 605–608 (1972).
Lüttgau, H. C. & Spiecker, W. J. Physiol., Lond. 296, 411–429 (1979).
Sanchez, J. A. & Stefani, E. J. Physiol., Lond. 283, 197–209 (1978).
Meves, H. & Vogel, W. J. Physiol., Lond. 235, 225–265 (1973).
Llinas, R., Steinberg, I. Z. & Walton, K. Biophys. J. 33, 289–321 (1981).
Spitzer, N. C. A. Rev. Neurosci. 2, 363–397 (1979).
Fleckenstein, A. A. Rev. Pharmac. Tox. 17, 149–166 (1977).
Ehara, T. & Kaufmann, R. J. Pharmac. exp. Ther. 207, 49–55 (1978).
McDonald, T. F., Pelzer, D. & Trautwein, W. Pflügers Arch. ges. Physiol. 385, 175–179 (1980).
Trautwein, W., Pelzer, D., McDonald, T. F. & Osterrieder, W. Naunyn-Schmiedebergs Archs Pharmak. 317, 228–232 (1981).
Osterrieder, W., Pelzer, D., Yang, Q.-F. & Trautwein, W. Naunyn-Schmiedebergs Archs Pharmak. 317, 233–237 (1981).
Hille, B. J. gen. Physiol. 69, 497–515 (1977).
Hondeghem, L. M. & Katzung, B. G. Biochim. biophys. Acta 472, 373–398 (1977).
Romey, G. & Lazdunski, M. Nature 297, 79–80 (1982).
Cohen, C. J., Bean, B. P., Colatski, T. J. & Tsien, R. W. J. gen Physiol. 78, 383–411 (1981).
Glossmann, H., Ferry, D. R., Lübbecke, F., Mewes, R., Hofmann, F. Trends pharmac. Sci. 3, 431–437 (1982).
Honerjäger, P. Rev. Physiol. Biochem. Pharmac. 92, 1–74 (1982).
Mudge, A. W., Leeman, S. & Fischbach, G. D. Proc. natn. Acad. Sci. U.S.A. 76, 526–530 (1979).
Werz, M. A. & Macdonald, R. L. Nature 299, 730–7333 (1982).
Michell, R. H. Nature 296, 492–493 (1982).
Mullins, L. J. Am. J. Physiol. 236, C103–C110 (1979).
Means, A. R. & Dedman, J. R. Nature 285, 73–77 (1980).
Kehoe, J. S. & Marty, A. A. Rev. Biophys. Bioengng 9, 437–465 (1980).
Hartzell, H. C. Nature 291, 539–544 (1981).
Llinas, R. Scient. Am. 247, 38–47 (1982).
Kandel, E. R. & Schwartz, J. H. Science 218, 433–443 (1982).
Akaike, N., Lee, K. S. & Brown, A. M. J. gen. Physiol. 71, 509–531 (1978).
Adams, D. J. & Gage, P. W. J. Physiol., Lond. 289, 143–161 (1979).
McDonald, T. F. A. Rev. Physiol. 44, 425–434 (1982).
Tsien, R. W. & Marban, E. in Advances in Pharmacology and Therapy Vol. 3 (eds Yoshida, H., Hagihara, Y. & Ebashi, S.) 217–225 (Pergamon, Oxford, 1982).
Stevens, C. F. A. Rev. Physiol. 42, 643–652 (1980).
Rodbell, M. Nature 284, 17–22 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Reuter, H. Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature 301, 569–574 (1983). https://doi.org/10.1038/301569a0
Issue Date:
DOI: https://doi.org/10.1038/301569a0
- Springer Nature Limited
This article is cited by
-
Cav1.2 regulated odontogenic differentiation of NG2+ pericytes during pulp injury
Odontology (2023)
-
Skeletal Functions of Voltage Sensitive Calcium Channels
Current Osteoporosis Reports (2021)
-
Presynaptic calcium channels: specialized control of synaptic neurotransmitter release
Nature Reviews Neuroscience (2020)
-
Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians
Scientific Reports (2019)
-
L-Type Calcium Channels Modulation by Estradiol
Molecular Neurobiology (2017)