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Regulation of nitrogen metabolism genes by nifA gene product in Klebsiella pneumoniae

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Abstract

The Klebsiella pneumoniae nifA gene product, which is known to activate expression of the nitrogen fixation (nif) structural genes, is shown here also to be able to substitute for the product of the gene glnG (ntrC) in the regulation of other nitrogen metabolism genes. An evolutionary relationship between the nifA and glnG genes is suggested.

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References

  1. Roberts, G. P. & Brill, W. J. A. Rev. Microbiol. 35, 207–235 (1981).

    Article  CAS  Google Scholar 

  2. Kennedy, C. et al. in Current Perspectives in Nitrogen Fixation (eds Gibson, A. H. & Newton, W. E.) 146–156 (Australian Academy of Science, Canberra, 1981).

    Google Scholar 

  3. Roberts, G. P. & Brill, W. J. J. Bact. 144, 210–216 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Dixon, R. et al. Nature 286, 128–132 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Buchanan-Wollaston, V., Cannon, M. C., Beynon, J. L. & Cannon, F. C. Nature 294, 776–778 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Buchanan-Wollaston, V., Cannon, M. C. & Cannon, F. C. Molec. gen. Genet. 184, 102–106 (1981).

    Article  CAS  PubMed  Google Scholar 

  7. Hill, S., Kennedy, C., Kavanagh, E., Goldberg, R. B. & Hanau, R. Nature 290, 424–426 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Merrick, M. et al. Molec. gen. Genet. 185, 75–81 (1982).

    Article  CAS  Google Scholar 

  9. Tyler, B. A. Rev. Biochem. 47, 1127–1162 (1978).

    Article  CAS  Google Scholar 

  10. Magasanik, B. A. Rev. Genet. 16, 135–168 (1982).

    Article  CAS  Google Scholar 

  11. Pahel, G. & Tyler, B. Proc. natn. Acad. Sci. U.S.A. 76, 4544–4548 (1979).

    Article  ADS  CAS  Google Scholar 

  12. Kustu, S., Burton, D., Garcia, E., McCarter, L. & McFarland, N., Proc. natn. Acad. Sci. U.S.A. 76, 4576–4580 (1979).

    Article  ADS  CAS  Google Scholar 

  13. Leonardo, J. M. & Goldberg, R. B. J. Bact. 142, 99 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. deBruijn, F. J. & Ausubel, F. M. Molec. gen. Genet. 183, 289 (1981).

    Article  CAS  Google Scholar 

  15. Espin, G., Alvarez-Mornales, A. & Merrick, M. Molec. gen. Genet. 184, 213 (1981).

    CAS  PubMed  Google Scholar 

  16. Rothman, N., Rothstein, D., Foor, F. & Magasanik, B. J. Bact. 120, 815–821 (1982).

    Google Scholar 

  17. Garcia, F., Bancroft, S., Rhee, S. G. & Kustu, S. Proc. natn. Acad. Sci. U.S.A. 74, 1662–1666 (1977).

    Article  ADS  CAS  Google Scholar 

  18. Gaiilardin, C. M. & Magasanik, B. J. Bact. 133, 1429 (1978).

    Google Scholar 

  19. McFarland, N., McCarter, L., Artz, S. & Kustu, S. Proc. natn. Acad. Sci. U.S.A. 78, 2135–2139 (1981).

    Article  ADS  CAS  Google Scholar 

  20. Pahel, G., Rothstein, D. M. & Magasanik, B. J. Bact. 150, 202–213 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Backman, K., Chen, Y. M. & Magasanik, B. Proc. natn. Acad. Sci. U.S.A. 78, 3743–3747 (1981).

    Article  ADS  CAS  Google Scholar 

  22. Chen, Y. M., Backman, K. & Magasanik, B. J. Bact. 150, 214–220 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Foor, F., Reuveny, Z. & Magasanik, B. Proc. natn. Acad. Sci. U.S.A. 77, 2636–2640 (1980).

    Article  ADS  CAS  Google Scholar 

  24. Reuveny, Z., Foor, F. & Magasanik, B. J. Bact. 146, 740–745 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Berk, A. J. & Sharp, P. A. Cell 12, 721–732 (1977).

    Article  CAS  PubMed  Google Scholar 

  26. Thomas, C. M., Meyer, R. & Helinski, D. R. J. Bact. 141, 213–222 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Casadaban, M., Chou, J. & Cohen, S. J. Bact. 143, 971–980 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Ausubel, F. M. et al. in Genetic Engineering (eds Setlow, J. K. & Hollaender, A.) 169–198 (Plenum, New York, 1982).

    Google Scholar 

  29. Sundaresan, V., Jones, J., Ow, D. & Ausubel, F. (in the press).

  30. MacNeil, D., Zhu, J. & Brill, W. J. Bact. 144, 348–357 (1981).

    Google Scholar 

  31. MacNeil, D. & Brill, W. J. Bact. 144, 744–751 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Bloom, F. R., Levin, M. S., Foor, F. & Tyler, B. J. Bact. 134, 569–577 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Riedel, G. R., Brown, S. & Ausubel, F. J. Bact. (in the press).

  34. Roberts, T. M. & Lauer, G. D. Meth. Enzym. 68, 473–482 (1979).

    Article  CAS  PubMed  Google Scholar 

  35. Reitzer, L. J. & Magasanik, B. J. Bact. 151, 1299–1313 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Ausubel, F. M. & Cannon, F. C. in Cold Spring Harb. Symp. quant. Biol. 45, 487–499 (1981).

    Google Scholar 

  37. Puhler, A. & Klipp, W. in Biology of Inorganic Nitrogen and Sulfur (eds Bothe, H. & Trebst, A.) 276–286 (Springer, Berlin, 1981).

    Book  Google Scholar 

  38. Magasanik, B. & Rothstein, D. M. in Glutamine: Metabolism, Enzymology, and Regulation (eds Mora, J. & Palacios, R.) 61 (Academic, New York, 1980).

    Book  Google Scholar 

  39. Riley, M. & Anilionius, A. A. Rev. Microbiol. 32, 519–560 (1978).

    Article  CAS  Google Scholar 

  40. Bachmann, B. J. & Low, K. B. Microbiol. Rev. 44, 1–56 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Matsumoto, H. & Tazaki, T. Jap. J. Microbiol. 14, 129–141 (1970).

    Article  CAS  PubMed  Google Scholar 

  42. Sundaresan, V., Ow, D. W. & Ausubel, F. M. Proc. natn. Acad. Sci. U.S.A. (submitted).

  43. Ow, D. W. et al. Proc. natn. Acad. Sci. U.S.A. (submitted).

  44. O'Gara, F. & Shanmugan, K. T. Biochem. biophys. Acta 437, 313–321 (1976).

    Article  CAS  PubMed  Google Scholar 

  45. Drummond, M., Clements, J., Merrick, M. & Dixon, R. Nature 301, 302–307 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  46. Merrick, M. EMBO J. (in the press).

  47. Ow, D. W. & Ausubel, F. M. Molec. gen. Genet. 180, 165–175 (1980).

    Article  CAS  PubMed  Google Scholar 

  48. Streicher, S. L., Shanmugam, K. T., Ausubel, F., Morandi, C. & Goldberg, R. B. J. Bact. 120, 815–821 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  49. Miller, J. H. in Experiments in Molecular Genetics, 162–172 (Cold Spring Harbor Laboratory, New York, 1972).

    Google Scholar 

  50. Bender, R. A., Jenssen, K. A., Blumenberg, M., Foor, F. & Magasanik, B. J. Bact. 129, 1001–1009 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

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  1. David W. Ow & Frederick M. Ausubel

    Present address: Department of Molecular Biology, Massachusetts General Hospital, Jackson 11, Boston, Massachusetts, 02114, USA

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  1. Department of Biology, Harvard University, Cambridge, Massachusetts, 02138, USA

    David W. Ow & Frederick M. Ausubel

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  1. David W. Ow
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  2. Frederick M. Ausubel
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Ow, D., Ausubel, F. Regulation of nitrogen metabolism genes by nifA gene product in Klebsiella pneumoniae. Nature 301, 307–313 (1983). https://doi.org/10.1038/301307a0

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