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Role of fimbrin and villin in determining the interfilament distances of actin bundles

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Abstract

From X-ray diffraction patterns the interfilament distances of native and reconstituted actin bundles, and of purified actin gels subjected to a range of g forces by centrifugation, have been obtained and compared. The results suggest that bundling proteins, such as villin or fimbrin, cross-link actin filaments around a minimum distance probably set by electrostatic repulsion.

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Author notes

  1. Paul Matsudaira

    Present address: MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK

Authors and Affiliations

  1. Max Planck Institute for Biophysical Chemistry, D-3400, Göttingen, FRG

    Paul Matsudaira, Lyndal K. Hesterberg & Klaus Weber

  2. Max Planck Institute for Medical Research, D-6900, Heidelberg, FRG

    Eckhard Mandelkow & Winfried Renner

Authors
  1. Paul Matsudaira
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  2. Eckhard Mandelkow
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  3. Winfried Renner
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  4. Lyndal K. Hesterberg
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  5. Klaus Weber
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Matsudaira, P., Mandelkow, E., Renner, W. et al. Role of fimbrin and villin in determining the interfilament distances of actin bundles. Nature 301, 209–214 (1983). https://doi.org/10.1038/301209a0

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  • DOI: https://doi.org/10.1038/301209a0

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