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The sequences of an expressed rat α-tubulin gene and a pseudogene with an inserted repetitive element

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Abstract

The rat genome contains two segments closely related to a rat α-tubulin mRNA. Both have been cloned and complete nucleotide sequences are presented. Analysis of the structure and sequence of one of these establishes it as a functional α-tubulin gene. The second segment is a processed α-tubulin pseudogene. Comparison of this pseudogene to the mRNA and gene coding for α-tubulin strongly suggests that a mature mRNA was involved in its origin. Features of the pseudogene and a dispersed repetitive element inserted within it possibly reflect a common RNA-mediated process of insertion.

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Authors and Affiliations

  1. Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Ihor Lemischka & Phillip A. Sharp

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  1. Ihor Lemischka
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  2. Phillip A. Sharp
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Lemischka, I., Sharp, P. The sequences of an expressed rat α-tubulin gene and a pseudogene with an inserted repetitive element. Nature 300, 330–335 (1982). https://doi.org/10.1038/300330a0

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  • DOI: https://doi.org/10.1038/300330a0

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