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Mechanism of activation of a human oncogene

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Abstract

The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.

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Author notes

  1. Esther H. Chang

    Present address: Department of Pathology, Uniformed Services University for the Health Sciences, Bethesda, Maryland, 20014, USA

Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Clifford J. Tabin, Scott M. Bradley, Cornelia I. Bargmann & Robert A. Weinberg

  2. Merck Laboratories, West Point, Pennsylvania, 19486, USA

    Alex G. Papageorge & Edward M. Scolnick

  3. Laboratories of Molecular Virology and Dermatology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Ravi Dhar, Douglas R. Lowy & Esther H. Chang

Authors
  1. Clifford J. Tabin
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  2. Scott M. Bradley
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  3. Cornelia I. Bargmann
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  4. Robert A. Weinberg
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  5. Alex G. Papageorge
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  6. Edward M. Scolnick
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  7. Ravi Dhar
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  8. Douglas R. Lowy
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  9. Esther H. Chang
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Tabin, C., Bradley, S., Bargmann, C. et al. Mechanism of activation of a human oncogene. Nature 300, 143–149 (1982). https://doi.org/10.1038/300143a0

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  • DOI: https://doi.org/10.1038/300143a0

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