Abstract
Acute transforming RNA tumour viruses represent genetic recombinants between type C retro viral sequences and transformation-specific sequences of cellular origin. Of the known mammalian cell-derived transforming genes (oncogenes), two have been shown to encode proteins with either intrinsic or highly associated tyrosine-specific protein kinase activity. One such gene, c-fes, is of cat cellular origin, while the second, c-abl, was derived from mouse cellular sequences. We now show that the human equivalents of c-fes and c-abl are localized on human chromosomes 15 and 9, respectively. These findings exclude the possibility that these transformation-related genes are clustered at a single locus within the human genome. It is of interest that both of these chromosomes are involved in specific rearrangements found in certain forms of human cancer.
Similar content being viewed by others
References
Coffin, J. M. et al. J. Virol. 40, 953–957 (1981).
Fedele, L. A., Even, J., Garon, C. F., Donner, L. & Sherr, C. J. Proc. natn. Acad. Sci. U.S.A.. 78, 4036–4040 (1981).
Groffen, J., Heisterkamp, N., Grosveld, F., Van de Ven, W. J. M. & Stephenson, J. R. Science 216, 1136–1138 (1982).
Shibuya, M., Hanafusa, T., Hanafusa, J. & Stephenson, J. R. Proc. natn. Acad. Sci. U.S.A. 77, 6536–6540 (1980).
Groffen, J., Heisterkamp, N., Shibuya, M., Hanafusa, H. & Stephenson, J. R. Virology (submitted).
Goff, S. P., Gilboa, E., Witte, O. N. & Baltimore, D. Cell 22, 777–785 (1980).
Stephenson, J. R., Kham, A. S., Sliski, A. H. & Essex, M. Proc. natn. Acad. Sci. U.S.A.. 74, 5608–5612 (1977).
Sherr, C. J., Todaro, G. J., Sliski, A. H. & Essex, M. Proc. natn. Acad. Sci. U.S.A.. 75, 1505–1509 (1978).
Witte, O. N., Rosenberg, N., Paskind, M., Shields, A. & Baltimore, D. Proc. natn. Acad. Sci. U.S.A. 75, 2488–2492 (1978).
Reynolds, F. H. Jr, Sacks, T. L., Deobagkar, D. N. & Stephenson, J. R. Proc. natn. Acad. Sci. U.S.A. 75, 3974–3978 (1978).
Van de Ven, W. J. M., Reynolds, F. H. Jr & Stephenson, J. R. Virology 101, 185–197 (1980).
Witte, O. N., Dasgupta, A. & Baltimore, D. Nature 283, 826–831 (1980).
Reynolds, F. H. Jr, Van de Ven, W. J. M. & Stephenson, J. R. J. biol. Chem. 255, 11040–11047 (1980).
Barbacid, M., Beemon, K. & Devare, S. G. Proc. natn. Acad. Sci. U.S.A. 77, 5158–5162 (1980).
Sefton, B. M., Hunter, T. & Raschke, W. C. Proc. natn. Acad. Sci. U.S.A. 78, 1552–1556 (1981).
Reynolds, F. H. Jr, Van de Ven, W. J. M. & Stephenson, J. R. J. Virol. 36, 374–386 (1980).
Witte, O. N., Goff, S., Rosenburg, N. & Baltimore, D. Proc. natn. Acad. Sci. U.S.A.. 77, 4993–4997 (1980).
Reynolds, F. H. Jr, Van de Ven, W. J. M., Hlomberg, J. & Stephenson, J. R. J. Virol. 37, 643–653 (1981).
Der, C. J., Krontiris, T. C. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 79, 3637–3640 (1982).
Parada, L. F., Tabin, C., Shin, C. & Weinberg, R. A. Nature 297, 474–478 (1982).
Franchini, G., Even, J., Sherr, C. J. & Wong-Stall, F. Nature 290, 154–157 (1981).
O'Brien, S. & Nash, W. Science 216, 257–265 (1982).
Rowley, J. D. A. Rev. Genet. 14, 17–39 (1980).
Sandberg, A. A. The Chromosomes in Human Cancer and Leukaemia (Elsevier, New York, 1980).
Fischinger, P. J. in Molecular Biology of RNA Tumor Viruses (ed. Stephenson, J. R.) 162–198 (Academic, New York, 1980).
Dalla-Favera, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4714–4717 (1982).
Solomon, E., Swallow, D., Burgess, S. & Evans, L. Ann. hum. Genet. 42, 273–281 (1979).
Solomon, E. et al. Somatic Cell Genet. 2, 125–140 (1976).
Jones, E. A., Goodfellow, P. N., Kennett, R. H. & Bodmer, W. F. Somatic Cell Genet. 2, 483–496 (1976).
Povey, S. et al. Ann. hum. Genet. 43, 241–248 (1980).
Whitehead, A. S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 5021–5025 (1982).
Goodfellow, P. N. et al. Nature 254, 267–269 (1975).
Hobart, M. J. et al. Ann. hum. Genet. 45, 331–335 (1981).
Carritt, B. & Povey, S. Cytogenet. Cell Genet. 23, 171–181 (1979).
Carritt, B. in Tissue Culture in Medical Research Vol. 2 (eds Richards, R. J. & Rajan, K. T.) 169–175 (Pergamon, Oxford, 1980).
Bobrow, M. & Cross, J. Nature 251, 74–79 (1974).
Casperson, T., Lomakka, G. & Zech, L. Hereditas 67, 89–102 (1971).
Goodfellow, P. N. & Solomon, E. in Monoclonal Antibodies in Clinical Medicine (eds McMichael, A. & Folve, J.) 365–393 (Academic, London, 1982).
Harris, H. & Hopkinson, D. A. Handbook of Enzyme Electrophoresis in Human Genetics (North-Holland, Amsterdam, 1976).
Giard, D. J. et al. J. natn. Cancer Inst. 51, 1417–1423 (1973).
Bernards, R. & Flavell, R. A. Nucleic Acids Res. 8, 1521–1533 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Heisterkamp, N., Groffen, J., Stephenson, J. et al. Chromosomal localization of human cellular homologues of two viral oncogenes. Nature 299, 747–749 (1982). https://doi.org/10.1038/299747a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/299747a0
- Springer Nature Limited
This article is cited by
-
Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials
Molecular Psychiatry (2023)
-
Second-Generation Tyrosine Kinase Inhibitors in First-Line Treatment of Chronic Myeloid Leukaemia (CML)
BioDrugs (2014)
-
Chronic Myeloid Leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 Activity
Leukemia (2010)
-
Molecular and cellular bases of chronic myeloid leukemia
Protein & Cell (2010)
-
Predicting the response of CML patients to tyrosine kinase inhibitor therapy
Current Hematologic Malignancy Reports (2009)